Antidiabetic Effectiveness Test of Andaliman Fruit (Zanthoxylum acanthopodium) Extract on Histopathological Changes in Peripheral Nerves: An In Vivo Study

Background: Diabetes mellitus (DM) is a chronic metabolic disease characterized by elevated blood sugar levels, and the increase in levels triggered low insulin production or ineffective use of body (relatively). Diabetic neuropathy complication that often attacks DM patients highest diabetes. This study aims to test effectiveness Andaliman fruit (Zanthoxylum acanthopodium) extract on improved histopathology Peripheral nerve alloxan-induced Wistar rats (Rattus norvegicus).
 Methods: an experimental using 24 rats, which were grouped into 6 groups (1: normal, 2: negative control, 3: positive 4-6: + andaliman 150mg/kgBW, 250 mg/kgBW, 350 mg /kgBB). Data analysis used SPSS determine differences histological conditions peripheral nerves.
 Results: The administration at dose mg/kgBW was most effective inhibiting proliferation Schwann cells, showed potential preventing progression diabetic neuropathy. also inflammatory process nerves, believed be responsible for cell damage.
 Conclusion: against improving nerves alloxane-induced norvegicus).